There is one statistic that has been shows to determine better than any other, who will live long and healthy, and who will die young - your homocysteine level. The primary nutrients demonstrated to control this are Vitamin B12, Vitamin B6, and Folic Acid. Please note the B12 in our formulation comes from Methylcobalamin which is not the same as the poorly absorbed cyanocobalamin found in cheap B12 products.