I have been taking the Golden Seal formula (with Cayenne) alongside Threelac for about a month and I believe it has greatly helped to improve my severe bouts of candida. I started off with 1 pill in the morning and 1 in the evening, with food, and am now taking 3 with breakfast and 3 with dinner. I feel less bloated, less puffy and I think the Golden Seal has something to do with this. I am very grateful for Mark's replying to my queries every time I have a question and offering good advice that so far seems always to have proven helpful and true