I have been using colosan powder in conjunction with threelac. The first day (a working day) I took a half level teaspoon first thing in the morning. This had an effect akin to taking several grams of vitamin C but not liquid stools. After two days I increased it to a heaped teaspoon. Wow! It is unbelievable for its ability to cleanse totally without producing the strong urge to find a toilet for fear of embarassment that laxatives promote. I would recommend this for anyone looking for the ultimate safe cleanse in pursuit of their best total health.