I don't personally have any problem with constipation/bowel regulation, but use Colosan for a general 'clean out' as and when I feel I need to. It has a positive effect on my energy levels and doesn't create any discomfort whatsoever. I take it first thing in the morning on an empty stomach with plenty of water (and lemon juice thereafter as directed) and it works within 3 - 5 hours. A great start to a 'detox' I find, especially if I've been overdoing it!