I had a real problem with fluid retention and bloating. I also had problems with a sensation of crawling skin and pudendal itching. Overall, my symptoms were consistent with leaky bowel syndrome, so I was advised to start a programme of Colosan, Threelac and Oxygen Elements Plus to help sort it out. With virtually immediate effect, the main symptoms abated. I think the Colosan was the single most effective agent for rapid effect, because with a couple of days of taking this product, my fluid retention started to sort out, followed shortly by the diminution of the skin crawling and pudendal itching. The only word of caution is to be careful with the recommended dose better to follow the supplementary advice given by the clinic because it is very potent stuff!