When I started taking golden seal formula I had already been on threelac and and byberry formula, and I had experienced some improvement, but the improvements were unstable. I started taking golden seal formula 2 months ago and have got better and better since then. My main symptoms, which overall are now about 2/3rd better than when I started were ezcema, itchy skin and mild depression. So far this has ben the most effective product I have used for candida.