I don't have any digestive issues at all, but take them to cleanse/detox when I have overdone things slightly/ Having previously taken the Colosan powder, I found this, in time to to be quite as effective, so reverted back to these and glad I did. I always take about 5 capsules in the morning on an empty stomach, followed with a glass of lemon water. They take approximately 2 - 5 hours to 'work', but there is no discomfort whatsoever and always feel more energised afterwards!