I am taking this to support a liver/kidney cleanse and a parasite cleanse, so currently taking 6-8 tablets twice a week. At first, they had me on the toilet several times the following morning and early afternoon. As time has gone on, it takes longer to get a reaction, and less seems to be passed. I wonder whether this is because they lose their potency once opened, or because it has actually done what it is supposed to do and cleaned me out. I hope the latter.