I used to take Colosan many years ago in the powder form which worked well for me. Then I moved on to Colosan Capsules as I couldn't stomach the powder anymore. They worked for a while but in 212 I decided to move onto Oxypowder as I didn't feel colosan was working that well. So I've now been taking Oxypowder regularly for about 4 years and it works brilliantly. I take about 6 or 7 capsules a couple of times a week and it gives me a regular clear out plus softens my stools for a few days. I'm on regular medication so constipation comes with the territory but Oxypowder really sorts this out for me. Great product.