I suffer from a long term genetic condition (sickle cell anaemia), which causes me to live with chronic joint and muscular pain. When I began taking serrapeptase, there was an immediate improvement in my pain symptoms. Some time later it was suggested to me to combine serrapeptase with nattokinase. Within a few days of adding this product, my symptoms went from "much better" to "completely gone". its made a huge difference to my life because prior to taking this combination, I didn't have a single day without pain or discomfort. Its improved my quality of life tremendously.